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Friday, July 31, 2020 | History

4 edition of Co-administration of NMDA receptor antagonists with neurotoxic amphetamine analogs found in the catalog.

Co-administration of NMDA receptor antagonists with neurotoxic amphetamine analogs

Gail Meredith Farfel

Co-administration of NMDA receptor antagonists with neurotoxic amphetamine analogs

protection against serotonergic toxicity mediated via hypothermia

by Gail Meredith Farfel

  • 61 Want to read
  • 9 Currently reading

Published .
Written in English

    Subjects:
  • Amphetamines.,
  • Methamphetamine.,
  • Cold -- Theraputic use.,
  • Rats -- Physiology.

  • Edition Notes

    Statementby Gail Meredith Farfel.
    Classifications
    LC ClassificationsMicrofilm 94/2692 (Q)
    The Physical Object
    FormatMicroform
    Paginationvii, 114 leaves
    Number of Pages114
    ID Numbers
    Open LibraryOL1242133M
    LC Control Number94628893

    Two selective 5-HT1A receptor antagonists, WAY and NDL, stimulate locomotion in rats acclimatised to their environment and alter their behaviour: A behavioural analysis. Psychopharmacology, (4), Graduate Center for Toxicology. University of Kentucky *Joint Appointment. I. General Information. Home Address: W. Brannon Rd., Nicholasville, KY

    Sensitivity to non-selective or subtype-selective NMDA receptor antagonists (MK, ifenprodil and Zn2+ ions) was not modified in EE. Finally, the analysis of NMDA receptor subunit mRNA expression in noradrenergic cell bodies of the locus coeruleus showed that NR1, NR2A, NR2B and NR2D subunits were unchanged, while NR2C decreased significantly. Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized MiceCited by:

    Scavenger Receptor B-I (SR-BI) is a multi-recognition receptor critical in cellular uptake of cholesterol ester from high density lipoprotein. Recently, we reported that SR-BI plays a role in the pulmonary immune response to lipopolysaccharide (LPS) but the contribution of SR-BI . Alcohol and Neurological Dysfunction Historically, it is well documented that acute alcohol intoxication could result in changes in regional brain function, as assessed by changes in glucose metabolism or cerebral blood flow (Volkow et al., , ), cognitive performance (Lau, Pihl, & Peterson, ; Lindman, Sjoholm, & Lang,


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Co-administration of NMDA receptor antagonists with neurotoxic amphetamine analogs by Gail Meredith Farfel Download PDF EPUB FB2

A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and does this by concomitantly inhibiting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT.

Abstract. The purpose of this chapter is to review the evidence that substituted amphetamines (AMPHs), such as methamphetamine (METH), have neurotoxic potential, discuss critical determinants of AMPH neurotoxicity, and consider possible mechanisms underlying the neurotoxic action of Cited by: The NMDA receptor NRa subunit is also known to possess the triple-arginine ER retention motif.

Whether the interaction of σ 1 Rs with ion channel subunits or GPCRs at the ER may hinder the double-arginine motif of σ 1 Rs, thus triggering the departure of the complex for the plasma membrane is an untested, but intriguing by: NMDA receptor antagonists such as MK and ketamine have been shown to induce changes in long-term potentiation (LTP) in a metaplastic fashion: both substances were able to enhance tetanus.

The effects of the non-N-methyl-D-aspartate (NMDA) agonist quisqualate (QUIS) and selective AMPA/kainate receptor antagonist 1-(aminophenyl)-methyl. Tramadol, sold under the brand name Ultram among others, is an opioid pain medication used to treat moderate to moderately severe pain.

When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. It is also available by injection. It may be sold in combination with paracetamol (acetaminophen) or as longer-acting ncy category: AU: C, US: C (Risk not ruled out).

DOM, also known as STP, carrying an amphetamine methyl group, had an active dose of mg, rather than the mg of mescaline, and a duration of hours. DOB had mg and hours. The 2C series without the amphetamine methyl had shorter milder activity, with a dose of 2C-B being mg and a duration of hrs.

Levo-tetrahydropalmatine (l-THP) It is well documented that both D 1 and D 2 receptors are critically involved in drug reward and addiction [3, 29, 30].However, clinical trials with D 1 - or D 2-like receptor antagonists have failed because of lack of therapeutic effect with D 1-like antagonists or severe side-effects with D 2-like antagonists - such as dysphoria, supression of natural Cited by:   “Ecstasy” [(±)-3,4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse.

Several reports raised the concern that MDMA has the ability to induce neurotoxic effects both in laboratory animals and humans.

Despite more than two decades of research, the mechanisms by which MDMA is neurotoxic are still Cited by: The amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is widely abused as a recreational drug due to its unique psychological effects.

Of interest, MDMA causes long-lasting deficits in neurochemical and histological markers of the serotonergic neurons in the brain of different animal species.

Such deficits include the decline in the activity of tryptophan hydroxylase Cited by: 2. Introduction. Inas in previous years, interest in the role of endogenous opiates in mediating behavior remained high.

Although much of the research focused on characterizing the role of opiate receptor types, there was a great deal of interest in the interactions between opiate Cited by: Ibogaine acts as a non-competitive NMDA receptor antagonist, while NMDA has been implicated in long lasting changes in neuronal function and in the physiological basis of drug addiction.

The purpose of this study was to verify if persistent changes in NMDA receptors could be shown in vivo and in vitro after a single administration of ibogaine. JPB2 - Pharmaceutical preparation for transdermal application containing a combination of active ingredients for treating Parkinson's disease - Google PatentsAuthor: ホルストマン,ミヒャエル, テオバルト,フランク.

Panels, Mini-Panels and Study Groups. A Genetic Model of NMDA Receptor Hypofunction The effects of buprenorphine were evaluated after pretreatment with opioid receptor antagonists or in. European Journal of Pharmacology, 97, – de Mendonça, A. and Ribeiro, J.A. () Adenosine inhibits the NMDA receptor-mediated excitatory postsynaptic potential in the hippocampus.

Brain Research,– The term "novel psychoactive substance" (or synthetic drug) refers to a new category of drugs on the market that have been created to circumvent existing laws on illicit drugs.

This course will provide the most up-to-date information available on novel psychoactive substances, including the evolution of synthetic drug use; demographic characteristics of novel psychoactive substance users; the.

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Full text of "A Multidisciplinary MXE Analysis" See other formats. Amphetamine-like drugs and chorea. Amphetamines (amphetamine, methamphetamine, methylenedioxymethamphetamine (MDMA)) result in both receptor and multiple neuroamine abnormalities in addition to structural changes visible on MRI (Walker et al., ).

Acute high-dose exposure to amphetamine results in high cyctoplasmic levels of dopamine Cited by: 5. CONCLUSION: The preclinical and clinical literature strongly suggests that rapid-acting antidepressants are the current focus of antidepressant drug discovery. Promising clinical findings exist for several compounds including ketamine and other NMDA receptor antagonists, scopolamine, and psilocybin.

Full text of "Problems of drug dependence, proceedings of the 63rd Annual Scientific Meeting, the College on Problems of Drug Dependence, Inc." See other formats.Classical Theories of Drug–Receptor Binding Interactions 78 Experimental Quantification of Drug–Receptor Binding Interactions 81 General Molecular Concepts of Drug Receptor Action 84 Receptor Action: Regulation, Metabolism, and Dynamics 90 Receptor Types as Determined by Molecular Mode of Action 92 Receptor Action.Slide Synthetic Cathinones are b‐keto (‘bk’) Analogs of Amphetamine This slide shows how rogue chemists can simply add another molecule to the The effects of co‐administration of 3,4‐ system at one of its receptors (a subtype called NMDA receptor), many functions of the brain are slowed down.

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